A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Production of single-cycle infectious SARS-CoV-2 through a trans-complemented repliconArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome approach BAC Cell cells clone coated Coronavirus-2 COVID-19 culture supernatant did not produce elicit expression generate IFN immune response infected cell Infection Infectious virus Live attenuated vaccine memory N protein nucleocapsid omicron overexpression plaques platform Production progeny provide Replication replicon rescued resulting RNA robust S protein SARS-CoV-2 single-cycle infectious virus. Strains transient expression transmission electron microscopy type I interferon Vaccine Viral RNA virion virus [DOI] 10.1002/jmv.28057 PMC 바로가기
Sputum characteristics of patients with severe COVID-19: report of two cases with immunocytochemical detection of SARS-CoV-2 spike proteinArticle Published on 2022-12-012022-11-15 Journal: Medical molecular morphology [Category] COVID19(2023년), SARS, 치료기술, [키워드] aggregation alveolar Analysis can be used CD68 Cell cells characteristics of patient chromatin COVID-19 cytological cytoplasmic definitive diagnosis double infection epithelial evaluated exclusion expression Herpe herpes simplex herpes simplex virus immunocytochemistry Inclusion infected cell Infection intranuclear multinuclear nuclear nuclei Patient performed pneumocyte positive protein A SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein severe COVID-19 simplex specimen sputum Sputum sample Sputum. staining These cells Treatment viral infection virus [DOI] 10.1007/s00795-022-00326-9 PMC 바로가기
Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing VirusArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome animal models antiviral therapeutics antivirals biology of SARS-CoV-2 Care caused comparable contagious coronavirus coronavirus disease COVID-19 cultured cells demonstrated detect Express expresse expressing expression level facilitate feasibility fluorescent Genes hACE2 hamster Health human Angiotensin-converting enzyme in vitro In vitro assay in vivo infected cell Infection K18 knowledge limitation luciferase luciferase reporter gene luciferase reporter genes mCherry monitoring neutralizing antibody overcome pandemic pathogenicity Protein recombinant reporter responsible robust SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection transgenic mice Transmission Transmission. Vaccine viral fitness viral infection virus wild-type [DOI] 10.1128/spectrum.02379-22 PMC 바로가기
The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infectionArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] 3D cultures activate added Air-liquid interface air-liquid interface (ALI) airway airway epithelium Antigen presentation antiviral immune response basolateral side cell type co-culture Contact Course Culture cytokine production cytokine release demonstrated driven by epithelial epithelial cells evaluate HAE hMDM hMDMs Human airway epithelium human airway epithelium (HAE) human monocyte-derived macrophage immune response in viral infected cell Infection Innate immunity lung Macrophage macrophages macrophages. phagocyte primary human airway recruitment Replication SARS-CoV-2 SARS-COV-2 infection Spread the SARS-CoV-2 tissue macrophage transfer virus virus replication [DOI] 10.3389/fimmu.2022.991991 PMC 바로가기
The Antiviral Effects of 2-Deoxy-D-glucose (2-DG), a Dual D-Glucose and D-Mannose Mimetic, against SARS-CoV-2 and Other Highly Pathogenic VirusesArticle Published on 2022-09-122022-11-15 Journal: Molecules [Category] SARS, 유전자 메커니즘, 진단, 치료제, [키워드] 2-deoxy-D-glucose 2-DG Activation Antiviral agents antiviral drug cause Cell change changes changes in coronavirus D-Mannose Effect Glucose Glycolysis glycosylation host cell infected cell Infection Influenza virus inhibitors limit mechanism metabolic shift Mimetic noroviruses novel analogs Other pathway pharmacokinetic reduce respond rhinoviruses SARS-CoV-2 target therapeutic approach upregulated viral infections Viral infections. Zika virus [DOI] 10.3390/molecules27185928 PMC 바로가기
Human coronaviruses disassemble processing bodiesArticle Published on 2022-08-232022-11-16 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] 229E caused cells characteristic common cold CoVs contribute coronavirus Coronavirus infection correlated CoVs cytokine cytoplasmic dysregulated dysregulation expression FIVE fluorescent Granule Human human coronavirus IL-6 immune response impacted infected cell Infection information innate immune response mechanism MERS mRNA transcripts NL63 OC43 processing Proinflammatory cytokine proinflammatory cytokines promote Protein respond responsible ribonucleoprotein RNA RNAs SARS-CoV SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein screened severe SARS-CoV-2 stability submission the N protein the viral nucleocapsid TNF transcript translation unique viral infection virus [DOI] 10.1371/journal.ppat.1010724 PMC 바로가기
Protease-Responsive Peptide-Conjugated Mitochondrial-Targeting AIEgens for Selective Imaging and Inhibition of SARS-CoV-2-Infected CellsArticle Published on 2022-08-232022-11-15 Journal: ACS Nano [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome aggregation Cell cleavage coronavirus cytotoxicity effective Efficiency Health imaging induce infected cell infected cells inhibition inhibitor lack M pro main protease mitigate mitochondrial mitochondrial targeting peptide peptide-conjugated AIEgen Plasmid Prevent probe protease recombinant proteins SARS-CoV-2 SARS-CoV-2-infected cell SARS-CoV-2-infected cells selective therapeutic process transfected with Treatment triggering Viral transmission virus virus theranostics. [DOI] 10.1021/acsnano.2c03219 PMC 바로가기
A simple model of COVID-19 explains disease severity and the effect of treatments Research Published on 2022-08-202022-10-05 Journal: Scientific Reports [Category] SARS, 바이오마커, 치료법, 치료제, [키워드] Administered administration Analysis Antiviral Asymptomatic Cell Clinical finding Clinical outcome condition COVID-19 damage-associated molecular pattern damaged cell DAMP DAMPs disease severity dysregulated effect of treatment effort explain expressing hyperinflammation hypoxia infected cell Infection Inflammation interferon response lack less likelihood mathematical molecular natural killer cell Neutrophil extracellular traps PAMP PAMPs pathogen pathogen-associated molecular pattern pathogenesis of COVID-19 producing SARS-COV-2 infection severe COVID-19 Treatment Treatment strategies Viral load [DOI] 10.1038/s41598-022-18244-2 [Article Type] Research
COVID-19 Adaptive Humoral Immunity Models: Weakly Neutralizing Versus Antibody-Disease Enhancement ScenariosCOVID-19 적응 체액 면역 모델: 약한 중화 대 항체 질병 강화 시나리오Article Published on 2022-08-132022-09-12 Journal: Acta biotheoretica [Category] SARS, 진단, [키워드] ADE Antibody disease enhancement Antibody-dependent enhancement approach COVID-19 disease Disease progression Effect enhancement Final immune immune response immune system implication infected cell neutralisation neutralising antibody Non-neutralizing antibodies proportion SARS-CoV-2 scenario Secondary infection vaccination viral clearance viral dynamics virus Virus - immune system interaction Virus model. [DOI] 10.1007/s10441-022-09447-1 PMC 바로가기 [Article Type] Article